ChemicalBook CAS DataBase List 4-Fluoro-3-nitrobenzoic acid

4-Fluoro-3-nitrobenzoic acid synthesis

7synthesis methods

Product Name:4-Fluoro-3-nitrobenzoic acid
CAS Number:453-71-4
Molecular formula:C7H4FNO4
Molecular Weight:185.11

456-22-4 Synthesis

456-22-4
472 suppliers
$10.00/100g

453-71-4
329 suppliers
$5.00/1g

Yield:453-71-4 90%

Reaction Conditions:

with sulfuric acid;potassium nitrate at 20;

Steps:

1.1

To a cold solution of 4-fluorobenzoic acid (50.0 g, 0.36 mol, 1.0 equiv) in concentrated H₂SO₄(180 ml) was added portionwise potassium nitrate (39.7 g, 0.39 mol, 1.1 equiv). The reaction mixture was stirred overnight at rt and then poured on crushed ice (800 g) with constant stirring. The resulting mixture was kept overnight at rt, filtered and washed thoroughly with water, and finally dried by making an azeotrope with toluene to yield 59.5 g (90%) of the title compound as a light yellow solid. ¹H NMR (400 MHz, DMSO): δ 7.69-7.74 (m, 1H), 8.29-8.32 (m, 1H), 8.56 (d, J=7.2 Hz, 1H), 13.75 (br s, 1H).

References:

US2008/249101,2008,A1 Location in patent:Page/Page column 20

1009-35-4 Synthesis