ChemicalBook CAS DataBase List 4-FLUORO-3-METHOXYBENZALDEHYDE

4-FLUORO-3-METHOXYBENZALDEHYDE synthesis

7synthesis methods

Product Name:4-FLUORO-3-METHOXYBENZALDEHYDE
CAS Number:128495-46-5
Molecular formula:C8H7FO2
Molecular Weight:154.14

128495-45-4
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$25.00/1g

128495-46-5
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$8.00/1g

Yield:128495-46-5 85%

Reaction Conditions:

with manganese(IV) oxide in dichloromethane; for 16 h;Heating / reflux;

Steps:

16 EXAMPLE 16; 4-FLUORO-3-METHOXYBENZALDEHYDE

(4-FLUORO-3-METHOXYPHENYL) METHANOL (5. 00G, 0. 03mol) and manganese dioxide (33.4g, 0. 38MOL) were stirred in DICHLOROMETHANE (100ml) under an atmosphere of nitrogen, at gentle reflux for 16 hours. The cooled reaction mixture was then filtered through arbacel and concentrated in vacuo to give the title compound as a white solid (4.18g, 0. 027MOL, 85%). 1H NMR (CDCI3, 400MHZ) 8 : 3.96 (s, 3H), 7.23 (d, 1H), 7.43 (m, 1 H), 7.50 (d, 1 H) 9.91 (s, 1H). Mpt: 61-63°C. Analysis found C, 62.18 ; H, 4.54%. C8H7FO2 requires C, 62.34 ; H, 4.58%.

References:

WO2004/52372,2004,A1 Location in patent:Page 72