4-(ethylsulphonyl)-2-nitrophenol synthesis

5synthesis methods

Product Name:4-(ethylsulphonyl)-2-nitrophenol
CAS Number:84996-11-2
Molecular formula:C8H9NO5S
Molecular Weight:231.23

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57311-38-3 Synthesis

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Yield:84996-11-2 100%

Reaction Conditions:

with nitric acid;acetic acid at 80; for 3 h;

Steps:

51.3 Step 3. 4-(ethylsulfonyl)-2-nitrophen

Step 3. 4-(ethylsulfonyl)-2-nitrophen Nitric acid (0.1 mL, 3 mmol) was added to a mixture of 4-(ethylsulfonyl)phenol (0.5 g, 3 mmol) in acetic acid (9 mL) at room temperature. The mixture was heated to 80 °C for 3 h then cooled to room temperature and partitioned between ethyl acetate and water. The combined organic layers were washed with brine, dried over MgSC , filtered, and concentrated to yield crude product. The product was crystallized from ethyl ether to afford 4-(ethylsulfonyl)-2-nitrophenol as a pale yellow solid (0.59 g, 100%). LCMS calculated for CsHioNOsS (M+H)⁺: m/z = 232.1; found: 232.0.

References:

WO2015/164480,2015,A1 Location in patent:Page/Page column 94