ChemicalBook CAS DataBase List 4-Chlorophthalimide

4-Chlorophthalimide synthesis

10synthesis methods

Product Name:4-Chlorophthalimide
CAS Number:7147-90-2
Molecular formula:C8H4ClNO2
Molecular Weight:181.58

0.01g of MnO2 catalyst, 0.5mmol of 1-indanone, 0.2g of ammonia water and 2g of chlorobenzene were added to a stainless steel autoclave with a polytetrafluoroethylene inner liner. The temperature was raised to 110 by automatic temperature controller, 0.6MPa oxygen was added and the reaction was continued for 4h. The pressure was kept constant during the reaction. The reaction product was analyzed using GC-MS with a 4-Chlorophthalimide yield of 85 %.

118-45-6 Synthesis

118-45-6
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$6.00/5g

7147-90-2
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$60.00/50mg

Yield:7147-90-2 99%

Reaction Conditions:

with choline chloride;urea at 140; for 1 h;Green chemistry;

Steps:

General reaction procedure

General procedure: DES ChCl/urea was synthesized as described in literature(Abbott et al. 2004). Briefly, choline chloride and urea with the molar ratio of 1:2 were stirred at 80 °C for 1 h until a clear and transparent solution was formed (Fig. 1). The obtained DES was used without additional purification. Into a 25-mL round-bottom flask were added ChCl/urea (5.19 g, 20 mmol), phthalic anhydride (1.48 g, 10 mmol) and urea (0.60 g, 10 mmol) in successive, then the mixture was heated at 140 °C for 1 h under vigorous stirring. The reaction progress was monitored by GC analysis. After reaction, the reaction mixture was cooled to room temperature, followed by addition of 2 mL of water. The DES was dissolved and the product was precipitated. The solid was collected by filtration and washed thoroughly with water. The white solid was dried thoroughly to afford the product in a yield of 84%. The DES was recovered by evaporation of water under vacuum, and subjected to next run. The product was received in a yield of yield of 95% in the second run.

References:

Liu, Luxiao;Zhang, Hong-Yu;Yin, Guohui;Zhang, Yuecheng;Zhao, Jiquan [Chemical Papers,2020,vol. 74,# 4,p. 1351 - 1357]

42348-86-7 Synthesis