4-CHLORO-5-(4-FLUOROPHENYL)THIENO[2,3-D]PYRIMIDINE synthesis

5synthesis methods

Product Name:4-CHLORO-5-(4-FLUOROPHENYL)THIENO[2,3-D]PYRIMIDINE
CAS Number:384351-45-5
Molecular formula:C12H6ClFN2S
Molecular Weight:264.71

35978-37-1 Synthesis

5-(4-FLUOROPHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE

35978-37-1
34 suppliers
$85.00/250mg

4-CHLORO-5-(4-FLUOROPHENYL)THIENO[2,3-D]PYRIMIDINE

384351-45-5
26 suppliers
$115.00/500mg

Yield:384351-45-5 80%

Reaction Conditions:

with phosphorus pentachloride;trichlorophosphate at 105;

Steps:

2.3.4 Substituted 4-chloro-thieno[2,3-d]pyrimidines (iv)

General procedure: A mixture of thienopyrimidinone (0.01 mol), POCl₃ (11 mL) and PCl₅ (1.5 g) was quickly heated to 105° C and boiled for 5-6 h. The solvent was evaporated. Dry product was dissolved in methylene chloride (12 mL) and neutralized by cold solution of NaOH (0.5 N). The organic phase was separated and dried over Na₂SO₄, filtered, and then solvent was evaporated in vacuum. The residue was crystallized from isopropyl alcohol. Yield 80%

References:

Ostrynska, Olga V.;Balanda, Anatoliy O.;Bdzhola, Volodymyr G.;Golub, Andriy G.;Kotey, Igor M.;Kukharenko, Olexander P.;Gryshchenko, Andrii A.;Briukhovetska, Nadiia V.;Yarmoluk, Sergiy M. [European Journal of Medicinal Chemistry,2016,vol. 115,p. 148 - 160]

403-42-9 Synthesis