
4-CHLORO-3-HYDROXY BUTYRONITRILE synthesis
11synthesis methods
- Product Name:4-CHLORO-3-HYDROXY BUTYRONITRILE
- CAS Number:105-33-9
- Molecular formula:C4H6ClNO
- Molecular Weight:119.55
Yield:105-33-9 92%
Reaction Conditions:
Stage #1: potassium cyanidewith sulfuric acid in water at 0 - 20; pH=7.7;
Stage #2: epichlorohydrin in water at 20;
Steps:
2 Example 2: Preparation of 4-CHLORO-3-HYDROXYBUTYRONITRILE (KCN/H 2 SO) 4
The title compound of 17.8 g (yield : 92%) was obtained according to substantial the same method as in Example 1 except using potassium cyanide instead of sodium cyanide. Chemical purity (GC): 96.7%
References:
WO2004/92114,2004,A1 Location in patent:Page 10