ChemicalBook CAS DataBase List 4-Bromopyridine

4-Bromopyridine synthesis

12synthesis methods

Product Name:4-Bromopyridine
CAS Number:1120-87-2
Molecular formula:C5H4BrN
Molecular Weight:158

19524-06-2
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Yield:1120-87-2 100%

Reaction Conditions:

with sodium hydroxide in water at 20; for 0.166667 h;

Steps:

4-Bromopyridine (S3)
A 25 mL one-neck round-bottom flask was charged with 2.00 g (10.3 mmol, 1.00 eq) 4-bromopyridinehydrochloride dissolved in 10 mL water. Slow addition of 2 mL 5M NaOH solution resulted in a yellowmixture of two layers, which was stirred at rt for 10 min. The mixture was extracted with Et2O (3 x 15 mL).The combined organic layers were dried over MgSO4 and concentrated in vacuo. The title compoundwas obtained in quantitative yield (1.62 g colorless liquid).

References:

Breinbauer, Rolf;Doler, Carina;Fuchs, Elisabeth;Grabner, Gernot F.;Mayer, Nicole;Melcher, Michaela-Christina;Migglautsch, Anna K.;Romauch, Matthias;Schweiger, Martina;Zechner, Rudolf;Zimmermann, Robert [Bioorganic and medicinal chemistry,2020,vol. 28,# 16] Location in patent:supporting information

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