4-BROMOPYRIDINE-2-CARBALDEHYDE synthesis
- Product Name:4-BROMOPYRIDINE-2-CARBALDEHYDE
- CAS Number:131747-63-2
- Molecular formula:C6H4BrNO
- Molecular Weight:186.01
131747-45-0
187 suppliers
$13.00/50mg
131747-63-2
170 suppliers
$25.00/250mg
Yield:131747-63-2 100%
Reaction Conditions:
with manganese(IV) oxide in chloroform for 0.75 h;Reflux;
Steps:
29.i 4-Bromopicolinaldehyde
Example 29i 4-Bromopicolinaldehyde Manganese(IV) oxide (22.19 g, 255.29 mmol) was added to a solution of (4-bromopyridin-2-yl)methanol (4.00 g, 21.27 mmol) in chloroform (80 mL) and the reaction mixture was stirred under reflux for 45 min. After the mixture had cooled to room temperature the solids were removed by filtration through a pad of Celite. The solvent was removed in vacuo and the residue (3.96 g, quant.) was used without further purification in the next step. 1H NMR (500 MHz, DMSO-d6) δ ppm 9.97 (s, 1H) 8.80 (d, 1H) 7.98 (d, 1H) 7.88 (dd, 1 H); MS (APCI+): m/z 186, 188 [M+H]+.
References:
ASTRAZENECA AB US2010/125082, 2010, A1 Location in patent:Page/Page column 24
1005342-94-8
12 suppliers
inquiry
131747-63-2
170 suppliers
$25.00/250mg
1885-14-9
346 suppliers
$10.00/1g
131747-63-2
170 suppliers
$25.00/250mg
22282-99-1
398 suppliers
$6.00/5g
131747-63-2
170 suppliers
$25.00/250mg
108338-19-8
50 suppliers
$112.00/100mg
131747-63-2
170 suppliers
$25.00/250mg