4-Bromobenzylamine synthesis

8synthesis methods

Product Name:4-Bromobenzylamine
CAS Number:3959-07-7
Molecular formula:C7H8BrN
Molecular Weight:186.05

1122-91-4
691 suppliers
$9.00/10g

3959-07-7
200 suppliers
$10.00/1g

Yield:3959-07-7 91%

Reaction Conditions:

with ammonium hydroxide;hydrogen in ethanol at 130; under 7500.75 Torr; for 12 h;Autoclave;

Steps:

2.4. General procedure of the reductive amination
General procedure: The reductive amination of carbonyl compounds was performed in a 50 mL stainless steel autoclave reactor. In a typical run, benzaldehyde (1 mmol), Co(at)NC-800 (20 mg), ethanol (8 mL) and NH3.H2O (26.5 wt%, 2 mL) were charged into the reactor, and then the autoclave reactor was closed. The reactor was flushed with H2 for several times to remove air, and then charged with 1 MPa H2 at room temperature. The reaction was then carriedout at 130 °C for 12 h with a stirring rate of 1000 RPM. After reaction,the reaction mixture was cooled down to room temperature and then depressurized. Then, the products in the reaction mixture were detected by gas chromatography by the use of ethylbenzene as the internal standard. The products were also identified by GC/MS (Shimadzu GCMS-QP2010) equipped with Agilent capillary column DB-5MS.

References:

Yuan, Ziliang;Liu, Bing;Zhou, Peng;Zhang, Zehui;Chi, Quan [Journal of Catalysis,2019,vol. 370,p. 347 - 356]

FullText