ChemicalBook CAS DataBase List 4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID

4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID synthesis

6synthesis methods

Product Name:4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID
CAS Number:29421-99-6
Molecular formula:C6H5BrO2S
Molecular Weight:221.07

1918-79-2
245 suppliers
$8.00/5g

4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID

29421-99-6
63 suppliers
$60.00/10mg

Yield:29421-99-6 100%

Reaction Conditions:

with iron(III) chloride;bromine in acetic acid at 25; for 5 h;

Steps:

9

A solution of bromine (725 uL, 14.1 mmol) in AcOH (2.8 ml.) was added dropwise to δ-methyl^-thiophenecarboxylic acid (2 g, 14.1 mmol) and FeCI₃ (456 mg, 2.81 mmol) in AcOH (28 ml.) at 25 ⁰C. After 5h, the solution was poured onto ice and the precipitate was filtered and washed with water affording the title compound (3 g, quant.) as a yellow powder: LCMS (ES) m/z 222 (M+H)⁺.

References:

WO2008/98104,2008,A1 Location in patent:Page/Page column 81

29421-73-6 Synthesis