4-BROMO-3'-METHOXYBENZOPHENONE synthesis

7synthesis methods

Product Name:4-BROMO-3'-METHOXYBENZOPHENONE
CAS Number:151239-47-3
Molecular formula:C14H11BrO2
Molecular Weight:291.14

(4-bromophenyl)(3-methoxyphenyl)methanol

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151239-47-3
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Yield:151239-47-3 94%

Reaction Conditions:

with 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in tetrahydrofuran at 60;

Steps:

4.3.1. Method B

General procedure: To a mixture of alcohol (1 equiv) in dry THF was added 2-iodoxybenzoic acid (2 equiv). The reaction mixture was stirred at 60 °C overnight, cooled to room temperature and quenched with Na₂S₂O₃. The aqueous layer was extracted with ethyl acetate and the organic layer was washed with water, neutralised with 0.5N NaOH and dried over sodium sulfate, filtered and concentrated to dryness. The product was purified by column chromatography or by recrystallisation.

References:

Wetzel, Marie;Gargano, Emanuele M.;Hinsberger, Stefan;Marchais-Oberwinkler, Sandrine;Hartmann, Rolf W. [European Journal of Medicinal Chemistry,2012,vol. 47,# 1,p. 1 - 17] Location in patent:experimental part