4'-BROMO-2'-NITROACETANILIDE synthesis
- Product Name:4'-BROMO-2'-NITROACETANILIDE
- CAS Number:881-50-5
- Molecular formula:C8H7BrN2O3
- Molecular Weight:259.06
Yield:881-50-5 99.1%
Reaction Conditions:
with acetic acid at 95; for 7.5 h;
Steps:
3.1 N-(4-bromo-2-nitrophenyl)acetamide
4-Bromo-2-nitroaniline 3a (30.3 g, 138 mmol) was dissolved in 240 mL of acetic acid, and acetic anhydride (22.44g, 220.2 mmol) was added, and the mixture was heated to 95 ° C for 7.5 hours. The reaction solution was cooled to room temperature and poured into 600 mL of ice water. After ice-melting, it was extracted with dichloromethane (90 mL×3), and the solid was dissolved in dichloromethane (600 mL), the organic phase was combined, dried over anhydrous sodium sulfate Concentration gave N-(4-bromo-2-nitrophenyl)acetamide 3b (35.4g, orange solid), yield: 99.1%.
References:
CN108264511,2018,A Location in patent:Paragraph 0243; 0246-0249
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