4-bromo-2-methoxy-1-nitrobenzene synthesis
- Product Name:4-bromo-2-methoxy-1-nitrobenzene
- CAS Number:103966-66-1
- Molecular formula:C7H6BrNO3
- Molecular Weight:232.03
67-56-1
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321-23-3
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124-41-4
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103966-66-1
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Yield: 100%
Reaction Conditions:
at 60; for 3 h;Temperature;
Steps:
1.1; 2.1; 3.1 (1) Synthesis of compound III
Add 220g (1mol) of 4-bromo-2-fluoro-1-nitrotoluene, 1000ml of methanol to the reaction flask, add 108g (2mol) of sodium methoxide to 60°C, keep the temperature for 3 hours, and HPLC track the reaction until 4 The reaction of bromo-2-fluoro-1-nitrotoluene is complete; the reaction solution is concentrated, 1000 ml of water is added, and 1000 ml of ethyl acetate are added for layering, and the organic phase is concentrated to obtain 232 g of compound III. The molar yield: 100%.
References:
CN112300028, 2021, A Location in patent:Paragraph 0032; 0034-0035; 0052; 0054-0055; 0070; 0072-0073
321-23-3
255 suppliers
$10.00/1g
124-41-4
705 suppliers
$12.00/25g
103966-66-1
125 suppliers
$7.00/100mg
2398-37-0
581 suppliers
$8.00/10g
98447-30-4
84 suppliers
$10.00/100mg
181995-71-1
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103966-66-1
125 suppliers
$7.00/100mg
67-56-1
760 suppliers
$7.29/5ml-f
321-23-3
255 suppliers
$10.00/1g
103966-66-1
125 suppliers
$7.00/100mg
2398-37-0
581 suppliers
$8.00/10g
98447-30-4
84 suppliers
$10.00/100mg
103966-66-1
125 suppliers
$7.00/100mg