4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE synthesis
- Product Name:4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
- CAS Number:287930-73-8
- Molecular formula:C11H13NO3
- Molecular Weight:207.23
298-12-4
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104-63-2
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287930-73-8
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Yield:287930-73-8 91%
Reaction Conditions:
in tetrahydrofuranReflux;
Steps:
1
To a 250ml reaction flask was added 50% glyoxylic acid (67ml, 0.61mol) and tetrahydrofuran (130ml), heated to reflux, was added dropwise N- benzyl ethanolamine (41.5g, 0.27mol) in tetrahydrofuran (20ml) solution, to the reaction complete, the tetrahydrofuran was evaporated, water (170ml), cooled with stirring, to precipitate a solid, ice-water bath was stirred for 30 minutes, filtered and washed with ice water, drying in a yellowish solid, i.e. compounds of formula VII (51.8g, 91%), mp132 ~ 136 .
References:
Jiangsu Hansoh Pharmaceutical Ltd.;Xu, Shiwei;Yuan, Fuping CN103030668, 2016, B Location in patent:Paragraph 0031-0033
110843-90-8
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287930-73-8
219 suppliers
$6.00/5g
104-63-2
344 suppliers
$7.00/10g
287930-73-8
219 suppliers
$6.00/5g
104-63-2
344 suppliers
$7.00/10g
563-96-2
288 suppliers
$6.00/25g
287930-73-8
219 suppliers
$6.00/5g