4-(AMINOMETHYL)PYRIDIN-3-OL synthesis
- Product Name:4-(AMINOMETHYL)PYRIDIN-3-OL
- CAS Number:20485-35-2
- Molecular formula:C6H8N2O
- Molecular Weight:124.14
87032-82-4
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20485-35-2
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Yield:20485-35-2 82.93%
Reaction Conditions:
with ammonia;hydrogen in methanol at 20; for 16 h;Reagent/catalyst;Solvent;
Steps:
40.3; 234.1 40.3. Synthesis of 4-(aminomethyl)pyridin-3-ol
4 mmol, 1.00 equiv) inNH3(g) in MeOH (100.00 mL)was added 3-hydroxypyridine-4-carbonitrile (2.10 g, 17.484 mmol, 1.00 equiv) under nitrogen atmosphere. The mixture was hydrogenated at room temperature for 16h under hydrogen atmosphere using a hydrogen balloon, filtered through a Celite pad and concentrated under reduced pressure to afford 4-(aminomethyl)pyridin-3-ol (1.8 g, 82.93%) as a grey solid. LC-MS: M+H found: 125.
References:
WO2022/66734,2022,A1 Location in patent:Page/Page column 372-373; 887
![4-Pyridinecarbonitrile, 3-[2-(trimethylsilyl)ethoxy]-](/CAS/20210305/GIF/945989-08-2.gif)
945989-08-2
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20485-35-2
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1849-54-3
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$44.00/1g
20485-35-2
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