ChemicalBook CAS DataBase List 4-Aminobenzyl alcohol

4-Aminobenzyl alcohol synthesis

14synthesis methods

Product Name:4-Aminobenzyl alcohol
CAS Number:623-04-1
Molecular formula:C7H9NO
Molecular Weight:123.15

619-45-4 Synthesis

619-45-4
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623-04-1
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$6.00/1g

Yield:623-04-1 93%

Reaction Conditions:

with C₃₉H₅₃ClN₂P₂Ru;potassium methanolate;hydrogen in tetrahydrofuran at 20; under 38002.6 Torr; for 16 h;Glovebox;Autoclave;

Steps:

29 Example 29: Hydrogenation of ester compounds catalyzed by ruthenium complex Il at room temperature
General procedure: In a glove box, add a ruthenium complex Il (0.75 mg, 0.001 mmol),Potassium methoxide (3.5 to 70 mg, 0.05 to 1 mmol), tetrahydrofuran (1 to 10 mL), and ester compounds (0.5 to 10 mmol).After sealing the autoclave, remove it from the glove box and fill it with hydrogen to the required pressure.The reaction vessel was stirred at room temperature for 16 to 24 hours.After slowly releasing excess hydrogen, the reaction solution was depressurized to remove the solvent, and the residue was purified by a short column of silica gel to obtain an alcohol compound.The results are shown in Table 7.

References:

Zhejiang Zhongke Chuangyue Pharmaceutical Co., Ltd.;Ding Kuiling;Tang Yitian;Han Zhaobin CN110357923, 2019, A Location in patent:Paragraph 0312-0315

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