4-AMINO-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL synthesis
- Product Name:4-AMINO-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL
- CAS Number:78027-00-6
- Molecular formula:C7H7N5S
- Molecular Weight:193.23
3690-46-8
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$65.00/100mg
78027-00-6
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$57.50/250mg
Yield:78027-00-6 78%
Reaction Conditions:
with hydrazine hydrate in ethanol; for 12 h;Reflux;
Steps:
2.B Step B: preparation of 4-amino-5 - (pyridin-3-yl) - 4H-1, 2, 4-triazole-3-thiol
250mL round bottom flask was added 8. 75g (55. 8mmol) 5- (pyridin-3-yl) -1,3,4_ oxadiazole-2-thiol, 20. 95g (334. 8mmol) hydrazine hydrate (80 %) and 100mL of absolute ethanol, heated under reflux for 12h. Rotary cooling to room temperature the solvent, the residue is taken after an appropriate amount of aqueous hydrochloric acid with pH 1~2, stirred at room temperature 30min, filtration, recrystallized from ethanol and dried to give 8. 41g of white solid, a yield of 78%.
References:
CN105330651,2016,A Location in patent:Paragraph 0048; 0049; 0050
614-18-6
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78027-00-6
30 suppliers
$57.50/250mg
553-53-7
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78027-00-6
30 suppliers
$57.50/250mg
75-15-0
253 suppliers
$40.00/100g
553-53-7
223 suppliers
$5.00/5g
78027-00-6
30 suppliers
$57.50/250mg
59-67-6
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$7.00/25g
78027-00-6
30 suppliers
$57.50/250mg