ChemicalBook CAS DataBase List 4-Amino-3-chlorophenylboronic acid, pinacol ester

4-Amino-3-chlorophenylboronic acid, pinacol ester synthesis

5synthesis methods

Product Name:4-Amino-3-chlorophenylboronic acid, pinacol ester
CAS Number:721960-43-6
Molecular formula:C12H17BClNO2
Molecular Weight:253.53

42016-93-3
214 suppliers
$15.00/5g

73183-34-3
575 suppliers
$6.00/5g

4-Amino-3-chlorophenylboronic acid, pinacol ester

721960-43-6
73 suppliers
$41.00/250mg

Yield: 74%

Reaction Conditions:

with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in 1,4-dioxane at 90; for 12 h;Inert atmosphere;

Steps:

5.1.9. General procedure G: syntheses of compounds 23a-23f
General procedure: The substituted aniline (22ae22f) (10.0 mmol, 1.0 eq), bis(pinacolato)diboron (12.0 mmol, 1.2 eq), potassium acetate(30.0 mmol, 3.0 eq) and PdCl2(dppf) (1.0 mmol, 0.1 eq) were suspendedin 1,4-dioxane (50 mL) under argon atmosphere and thereaction mixture was heated to 90 C for 12 h. The crude mixturewas filtered through a thin plug of Celite. The Celite plug waswashed with ethyl acetate and filtrate was concentrated. Theresulting residue was purified by silica gel chromatography (petroleumether/ethyl acetate, v/v, 98:2) to give the desired product.

References:

Ai, Jing;Duan, Wenhu;Geng, Meiyu;Ji, Yinchun;Peng, Xia;Shen, Yanyan;Sun, Deqiao;Wang, Wei;Xu, Dandan;Zhan, Zhengsheng [European Journal of Medicinal Chemistry,2021,vol. 220,art. no. 113497]

38762-41-3 Synthesis