4-AMINO-2-MERCAPTOPYRIMIDINE synthesis
- Product Name:4-AMINO-2-MERCAPTOPYRIMIDINE
- CAS Number:333-49-3
- Molecular formula:C4H5N3S
- Molecular Weight:127.17
Yield: 48%
Reaction Conditions:
with sodium in butan-1-ol at 40 - 50; for 5 h;Inert atmosphere;
Steps:
3 Example 3
Preparation of 2-thiocytosine
Under the protection of nitrogen, at 40 ~ 50 ,To n-butanol (88 mL) was added sodium metal (4.8 g)After stirring, the reaction solution was added with thiourea (16 g)3,3-diethoxypropanenitrile (28 g),Heated to reflux for 5 hours, cooled to room temperature,With acetic acid to adjust the pH to 7 ~ 8, filtered to give a yellow solid,Recrystallization from water gave pale yellow 2-thiocytosine (12 g) in 48% yield.
References:
Yangzhou Xiruien Bio-pharmaceutical Technology Co., Ltd.;Huang Zhen;Yue Sefu·shalong;Yang Zhaoyi;Liu Daxue CN106336443, 2017, A Location in patent:Paragraph 0040; 0057-0060
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