4,6-Dichloro-2-pyridinecarboxylic acid synthesis
- Product Name:4,6-Dichloro-2-pyridinecarboxylic acid
- CAS Number:88912-25-8
- Molecular formula:C6H3Cl2NO2
- Molecular Weight:192
98273-19-9
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Yield:88912-25-8 98.7%
Reaction Conditions:
with sodium hydroxide in ethanol;water
Steps:
S.20.3 (3)
(3) Synthesis of 4,6-Dichloropicolinic Acid [Compound (II-17)] 4,6-Dichloropicolinic acid methyl ester (0.5 g, 2.43 mmol) was stirred in a mixture of sodium hydroxide (0.11 g, 2.43*1.1 mmol), 1.1 ml of water and 11 ml of ethanol at 60° C. for 1 hour. Ethanol in the reaction solution was distilled off and the residue was washed with dichloromethane. The aqueous layer was acidified with diluted hydrochloric acid. After being extracted with ethyl acetate, the product was washed with saturated saline solution and dried with sodium sulfate. White solid, yield: 0.46 g, percent yield: 98.7%, m.p.: 114-116° C. IR KBr cm-1: 3562, 1692, 1557, 1395, 1287, 819.
References:
Kureha Kagaku Kogyo K.K. US6610853, 2003, B1
98138-06-8
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99-32-1
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88912-25-8
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41600-42-4
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6317-46-0
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88912-25-8
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