4,5-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID synthesis
- Product Name:4,5-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID
- CAS Number:231295-84-4
- Molecular formula:C9H5Cl2NO2
- Molecular Weight:230.05
53995-85-0
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231295-84-4
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Yield:231295-84-4 60%
Reaction Conditions:
with lithium hydroxide in ethanol;
Steps:
72 (4,5-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
4,5-Dichloro-1H-indole-2-carboxylic acid ethyl ester (0.5 g) was teated with 1M lithium hydroxide in ethanol (3 mL) and heated, water bath, for 2 h. The solution was acidified with 10% hydrochloric acid, diluted with water and extracted with ethylacetate. The organic extracts were combined, dried over sodium sulfate and filtered, and solvent was evaporated to give 4,5-dichloro-1H-indole-2-carboxylic acid (0.27 g, 60%).
References:
US2003/207893,2003,A1
13124-18-0
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231295-84-4
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![Propanoic acid, 2-[2-(3,4-dichlorophenyl)hydrazinylidene]-, ethyl ester](/CAS/20210305/GIF/337957-48-9.gif)
337957-48-9
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231295-84-4
28 suppliers
$45.00/50mg