ChemicalBook CAS DataBase List 4-(4-METHYLPHENOXY)BENZOIC ACID

4-(4-METHYLPHENOXY)BENZOIC ACID synthesis

14synthesis methods

Product Name:4-(4-METHYLPHENOXY)BENZOIC ACID
CAS Number:21120-65-0
Molecular formula:C14H12O3
Molecular Weight:228.24

37563-42-1
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21120-65-0
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Yield:21120-65-0 100%

Reaction Conditions:

with dihydrogen peroxide;potassium hydroxide in methanol;ethanol;Reflux;

Steps:

Generalprocedure for the synthesis of 12a-b

General procedure: To a solution of the 4-phenoxybenzonitrile derivative (1 mmol) and KOH (20 mmol) in MeOH (0.6 mL) and EtOH (2.6 mmol), H₂O₂30% (1 mL) was added dropwise. The reaction mixture was refluxed for 4h30. After cooling to room temperature, the mixture was acidized with HCl 3M to pH 1and the product was extracted with CH₂Cl₂. The organic layer was dried with anhydrous Na₂SO₄ and concentrated under reduced pressure to give the product.

References:

Carrasco, Marta P.;Newton, Ana S.;Gon?alves, Lídia;Góis, Ana;Machado, Marta;Gut, Jiri;Nogueira, Fátima;H?nscheid, Thomas;Guedes, Rita C.;Dos Santos, Daniel J.V.A.;Rosenthal, Philip J.;Moreira, Rui [European Journal of Medicinal Chemistry,2014,vol. 80,p. 523 - 534] Location in patent:supporting information