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ChemicalBook CAS DataBase List 4-(4-fluorophenyl)piperidine-2,6-dione
163631-01-4

4-(4-fluorophenyl)piperidine-2,6-dione synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 1.) piperidine, 2.) KOH / 1.) RT, 3 days, 2.) water, 80 deg C - 85 deg C, 2 h
2: 1.) urea, 2.) ethanol / 1.) 160 deg C - 180 deg C, 2 h, 2.) reflux, 10 min

References:

Perregaard;Moltzen;Meier;Sanchez [Journal of Medicinal Chemistry,1995,vol. 38,# 11,p. 1998 - 2008]