4-(4-CHLOROPHENYL)PIPERIDINE-4-CARBONITRILE synthesis
- Product Name:4-(4-CHLOROPHENYL)PIPERIDINE-4-CARBONITRILE
- CAS Number:91721-16-3
- Molecular formula:C12H13ClN2
- Molecular Weight:220.7
218451-34-4
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91721-16-3
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Yield:91721-16-3 100%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 72 h;
Steps:
30.e e) 4-(4-chlorophenyl)-4-cyanopiperidine
e) 4-(4-chlorophenyl)-4-cyanopiperidine. A solution containing 1-N-Boc-4-(4-chlorophenyl)-4-cyanopiperidine (1.32 g, 4.11 mmol), TFA (11 mL), and DCM (11 mL) was stirred at RT for 72 h, and then concentrated. The residue was treated with water and sat. aq. sodium bicarbonate (until basic), then extracted with DCM (3X). The DCM extracts were dried (Na2SO4), filtered, and concentrated to give the title compound (quant. ) as a colored oil. MS m/z 221 (M+H).
References:
WO2004/22539,2004,A1 Location in patent:Page 34
![4-Piperidinecarbonitrile, 4-(4-chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-](/CAS/20211123/GIF/644981-92-0.gif)
644981-92-0
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91721-16-3
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