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ChemicalBook CAS DataBase List 4-(2-METHOXYETHOXY)ANILINE
33311-29-4

4-(2-METHOXYETHOXY)ANILINE synthesis

7synthesis methods
-

Yield: 76.9%

Reaction Conditions:

with dimethyl sulfoxide;potassium hydroxide at 60;

Steps:

7 Synthesis of intermediate 4- (2-methoxyethoxy) aniline
P-fluoronitrobenzene (0.5g, 3.54mmol),Ethylene glycol methyl ether (0.335ml, 4.25mmol), potassium hydroxide (0.3g, 5.31mmol) was added to 10ml of dimethyl sulfoxide, stirred at 60 overnight, water analysis, suction filtration0.537 g of a yellow solid was obtained with a yield of 76.9%.

References:

China Pharmaceutical University;Xiang Hua;Teng Yu;Li Zhenbang;Xiao Maoxu;Ren Shengnan;Ha Si;Tong Chao CN111057021, 2020, A Location in patent:Paragraph 0088-0090

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