2-(3-Pyridyl)-4-thiazolecarboxylic acid ethyl ester synthesis
- Product Name:2-(3-Pyridyl)-4-thiazolecarboxylic acid ethyl ester
- CAS Number:39067-28-2
- Molecular formula:C11H10N2O2S
- Molecular Weight:234.27
4621-66-3
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70-23-5
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39067-28-2
21 suppliers
$317.00/250mg
Yield:39067-28-2 83%
Reaction Conditions:
in toluene; for 5 h;Heating / reflux;
Steps:
1
[embodiment 1] N-phenyl-2-(pyridine-3-il)thiazole-4-carboxamide Ethyl-3-bromo-2-oxo-propionate (10Og, 0.51 mol) and pyridine-3- carbothioamide (7Og, 0.51 mol) were dissolved in toluene 500 rai and then refluxed for 5 hours. After completion of the reaction, the toluene was disti Hated under reduced pressure, and dichloromethanedOOO m-O was drop- added to the remaining material. The mixture was mixed and washed with water 1000 mi, dried with anhydrous manganese (10Og), then filtered and concentrated to be crystallized into hexane and then again filtered, thereby providing ethyl-2-(pyridine-3-il)thiazole-4-carboxylate 99.7g (yield=83%).
References:
WO2007/52882,2007,A1 Location in patent:Page/Page column 11
4621-66-3
219 suppliers
$13.00/5g
15933-07-0
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$8.00/1g
39067-28-2
21 suppliers
$317.00/250mg