4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde oxime synthesis
- Product Name:4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde oxime
- CAS Number:33097-12-0
- Molecular formula:C6H5Cl2N3OS
- Molecular Weight:238.09
33097-11-9
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$17.00/250mg
33097-12-0
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$180.25/1gm:
Yield:33097-12-0 80%
Reaction Conditions:
with hydroxylamine hydrochloride;acetic acid in ethanol at 20 - 60; for 2 h;
Steps:
57.57a
To the mixture of hydroxylamine hydrochloride (139 mg, 2.0 mmol), HOAc (0.113 mL, 2.0 mmol) and EtOH (5 mL) was added 4,6-dichloro-2-(methylthio)-5- pyrimidinecarbaldehyde (223 mg, 1.0 mol) to room temperature. The solution was then heated at 50 0C for about 1 hour, 60 0C for about 30 minutes and 70 0C for about 30 minutes before it was concentrated under vacuum and washed with H2O (10-20 mL) to afford 4,6-dichloro-2-(memylthio)-5-pyrimidinecarbaldehyde.oxime (190 mg, 80%). LC-MS m/z 238 (M + H)+ 1.57 minute, 1.65 minute; 1H-NMR (CDCl3) δ 2.62, 2.65 (3 H), 7.53, 8.30 (1 H).
References:
WO2006/104917,2006,A2 Location in patent:Page/Page column 81-82
1979-98-2
235 suppliers
$14.00/5g
33097-12-0
20 suppliers
$180.25/1gm: