(2S)-2-(2,2-dimethylpropanamido)-4-methylpentanoic acid synthesis
- Product Name:(2S)-2-(2,2-dimethylpropanamido)-4-methylpentanoic acid
- CAS Number:33019-84-0
- Molecular formula:C11H21NO3
- Molecular Weight:215.29
61-90-5
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Yield:33019-84-0 91%
Reaction Conditions:
Stage #1: L-leucine;pivaloyl chloridewith sodium hydroxide in water at 0 - 20;
Stage #2: with hydrogenchloride in water;
References:
Shi, Bing-Feng;Maugel, Nathan;Zhang, Yang-Hui;Yu, Jin-Quan [Angewandte Chemie - International Edition,2008,vol. 47,# 26,p. 4882 - 4886] Location in patent:supporting information; experimental part