3-tert-Butoxy-3-oxopropanoic acid synthesis
- Product Name:3-tert-Butoxy-3-oxopropanoic acid
- CAS Number:40052-13-9
- Molecular formula:C7H12O4
- Molecular Weight:160.17
2033-24-1
654 suppliers
$6.00/25g
75-65-0
753 suppliers
$10.00/10ml
40052-13-9
244 suppliers
$6.00/5g
Yield:40052-13-9 100%
Reaction Conditions:
for 6 h;Reflux;
Steps:
2 4.2 1-tert-Butyl malonate 6
A 200 mL round-bottom flask equipped with a stirring bar was charged with 2,2-dimethyl-1,3-dioxane-4,6-dione 5 (Meldrum's acid, 5.0 g, 34.7 mmol) and tert-butyl alcohol (40 mL). The reaction was allowed to stir for 6 h at reflux conditions. The reaction mixture was concentrated in vacuo to afford the desired product 6 (5.56 g, 100%) as a colorless oil. 1H NMR (400 MHz, CDCl3) δ 10.51 (br s, 1H), 3.35 (s, 2H), 1.42 (s, 9H); 13C NMR (100 MHz, CDCl3) δ 171.8, 166.3, 81.9, 42.1, 27.9; HR-FAB MS calcd for C7H13O4 [M+H]+ 161.0814, found 161.0809.
References:
Kanemitsu, Takuya;Furukoshi, Saeka;Miyazaki, Michiko;Nagata, Kazuhiro;Itoh, Takashi [Tetrahedron Asymmetry,2015,vol. 26,# 4,p. 214 - 218]
141-82-2
752 suppliers
$5.00/25g
75-65-0
753 suppliers
$10.00/10ml
40052-13-9
244 suppliers
$6.00/5g
55514-11-9
23 suppliers
$150.00/25mg
40052-13-9
244 suppliers
$6.00/5g
540-88-5
365 suppliers
$22.00/25mL
141-82-2
752 suppliers
$5.00/25g
40052-13-9
244 suppliers
$6.00/5g
