3-HYDROXYMETHYL-4-METHOXY-BENZALDEHYDE synthesis
- Product Name:3-HYDROXYMETHYL-4-METHOXY-BENZALDEHYDE
- CAS Number:76646-42-9
- Molecular formula:C9H10O3
- Molecular Weight:166.17
52577-09-0
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76646-42-9
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Yield:76646-42-9 83%
Reaction Conditions:
with sodium hydrogencarbonate in water;Reflux;
Steps:
4-Alkoxy-3-hydroxymethylbenzaldehydes 3a-c (general procedure).
General procedure: A mixture of the corresponding chloromethyl derivative 2a-c (0.01 mol) and a 2% aqueous solution of sodium hydrogencarbonate (100 mL) was refluxed for 3-4 h with stirring (TLCmonitoring). After cooling of the reaction mixture, the white crystals formed were filtered off and dried in air. Yields and physicochemical characteristics of products 3a-c are given in Table 1.
References:
Khachatryan;Razinov;Kolotaev;Belus?;Matevosyan [Russian Chemical Bulletin,2015,vol. 64,# 2,p. 395 - 404][Izv. Akad. Nauk, Ser. Khim.,2015,# 2,p. 395 - 404,10]
123-11-5
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