ChemicalBook CAS DataBase List 3-Hydroxyazetidine hydrochloride

3-Hydroxyazetidine hydrochloride synthesis

8synthesis methods

Product Name:3-Hydroxyazetidine hydrochloride
CAS Number:18621-18-6
Molecular formula:C3H8ClNO
Molecular Weight:109.55

3-Hydroxyazetidine hydrochloride is high in purity, and is a white solid.It is synthesised by t-butylamine and epichlorohydrin as raw materials, and performing a cyclization reaction, an acetyl reaction, and a desacetyl reaction successively to give 3-hydroxyazetidine hydrochloride.

1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride

90604-02-7
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18621-18-6
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$8.00/5g

Yield:18621-18-6 94%

Reaction Conditions:

with hydrogen;palladium hydroxide on carbon in ethanol at 20; under 3040.2 Torr; for 12 h;

Steps:

2
A solution of l-(diphenylmethyl)-3-hydroxyazetidine hydrochloride (11.8 g) in absolute ethanol (700 mL) was hydrogenated at room temperature over Pd(OH)2/C in a Parr shaker at 4 atm. After 12 hr the catalyst was filtered off and the filtrate evaporated to dryness to give3-hydroxyazetidine hydrochloride (4.20 g, 94%). ¹H-NMR (300 MHz, DMSO-de, ppm from TMS): δ 9.07 (2H, bb), 6.19 (IH, bb), 4.49 (IH, m), 3.99 (2H, m), 3.71 (2H, m).

References:

SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. WO2007/118830, 2007, A1 Location in patent:Page/Page column 91

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