ChemicalBook CAS DataBase List 3-FURANCARBONITRILE, TETRAHYDRO-

3-FURANCARBONITRILE, TETRAHYDRO- synthesis

11synthesis methods

Product Name:3-FURANCARBONITRILE, TETRAHYDRO-
CAS Number:14631-44-8
Molecular formula:C5H7NO
Molecular Weight:97.12

871677-92-8 Synthesis

871677-92-8
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Yield: 84%

Reaction Conditions:

with titanium tetrachloride in 5,5-dimethyl-1,3-cyclohexadiene at 20 - 50; for 1.16667 h;Reagent/catalyst;Solvent;Temperature;

Steps:

1.2; 2.2; 3.2; 4.2; 5.2
The off-white solid (4.24g, 3-formamide tetrahydrofuran 0.035mol) obtained in step (1) was dissolved in xylene (50mL), and titanium tetrachloride (7.7mL, 0.07 mol), after the dropping, stir at room temperature for 10 minutes, then heat to 50°C and stir for 60 minutes. After the reaction is over, wash with 20 mL of water three times. After separating the organic phase, distill under reduced pressure to collect 3.22 g of light yellow oily liquid, which is 3 -Cyanotetrahydrofuran, purity 89%, yield 84%

References:

Anhui Zhongtangtanyi Industry Technology Co., Ltd.;Liu Xianwei;Ma Qingsong;Ma Xinwang;Sun Dongyan;Wei Lijing;Su Jian;Liu Jiao CN111303083, 2020, A Location in patent:Paragraph 0054; 0057; 0061; 0064; 0066; 0069; 0071; 0074

143-33-9 Synthesis