3-Fluoro-4-methoxyphenylacetic acid synthesis
- Product Name:3-Fluoro-4-methoxyphenylacetic acid
- CAS Number:452-14-2
- Molecular formula:C9H9FO3
- Molecular Weight:184.16
404-90-0
121 suppliers
$7.00/100mg
452-14-2
127 suppliers
$8.00/1g
Yield:452-14-2 96%
Reaction Conditions:
with potassium hydroxide in ethanol;water for 5 h;Reflux;
Steps:
6.2. 2-(3-Fluoro-4-methoxyphenyl)acetic acid (9)
3-fluoro-4-methoxyphenylacetonitrile (42 g, 0.25 mol) was heated for 5 h with a solution of 32 g of potassium hydroxide in 120 mL of ethanol and 30 mL of water. After distillation of ethanol, the residue was diluted by water to a volume of 175 mL. The solution was filtered over the charcoal and the filtrate was acidified by 50% H2SO4. The resulting solid was filtered and dried, yield 45.0 g(96%); M.p. 110-114 °C. MS (ESI) m/z (%): 185.1 [M+H]+.
References:
Liao, Weike;Xu, Chen;Ji, Xiaohui;Hu, Gang;Ren, Lixiang;Liu, Yajing;Li, Ruijuan;Gong, Ping;Sun, Tiemin [European Journal of Medicinal Chemistry,2014,vol. 87,p. 508 - 518]
345-72-2
23 suppliers
$131.00/250mg
452-14-2
127 suppliers
$8.00/1g
321-28-8
370 suppliers
$6.00/1g
452-14-2
127 suppliers
$8.00/1g
351-52-0
109 suppliers
$61.00/5g
452-14-2
127 suppliers
$8.00/1g