ChemicalBook CAS DataBase List 3-Fluoro-4-hydroxybenzaldehyde

3-Fluoro-4-hydroxybenzaldehyde synthesis

5synthesis methods

Product Name:3-Fluoro-4-hydroxybenzaldehyde
CAS Number:405-05-0
Molecular formula:C7H5FO2
Molecular Weight:140.11

351-54-2
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$10.00/1g

405-05-0
236 suppliers
$12.00/1g

Yield:405-05-0 97%

Reaction Conditions:

with water;hydrogen bromide at 140; for 3 h;Inert atmosphere;

Steps:

3-Fluoro-4-hydroxybenzaldehyde (15)
3-Fluoro-4-methoxybenzaldehyde 14 (5.00 g, 32.5 mmol) was mixed with 48% (0088) HBr (30 ml_), heated to 140 °C and stirred under argon atmosphere for 3 h. The mixture was diluted with water (150 ml_) and extracted with dichloromethane (2x100 mL). The combined organic layers were washed with brine solution and dried over sodium sulfate. The solvent was removed in vacuo to give compound 15 as a brown solid (4.36 g, 30.2 mmol, 97% yield). NMRs are in accordance to literature. (Jiang 2014) ESI-MS (m/z): 141.00 [M+H]⁺.

References:

JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG;CHEN, Xinyu;DECKER, Michael;HIGUCHI, Takahiro WO2020/148154, 2020, A1 Location in patent:Page/Page column 13; 14

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367-12-4 Synthesis