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ChemicalBook CAS DataBase List 3'-Fluoro-3'-deoxythymidine Monophosphate
25520-83-6

3'-Fluoro-3'-deoxythymidine Monophosphate synthesis

5synthesis methods
42214-24-4 Synthesis
5'-O-TRITYL-3'-O-MESYLTHYMIDINE

42214-24-4
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3'-Fluoro-3'-deoxythymidine Monophosphate

25520-83-6
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 17 percent / NaOH
2: DAST; pyridine / CH2Cl2
3: aq. AcOH / 90 °C
4: POCl3; (MeO)3PO

References:

Vanheusden, Veerle;Munier-Lehmann, Helene;Pochet, Sylvie;Herdewijn, Piet;Van Calenbergh, Serge [Bioorganic and Medicinal Chemistry Letters,2002,vol. 12,# 19,p. 2695 - 2698]

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