ChemicalBook CAS DataBase List 3-CYANOBENZYL ALCOHOL

3-CYANOBENZYL ALCOHOL synthesis

10synthesis methods

Product Name:3-CYANOBENZYL ALCOHOL
CAS Number:874-97-5
Molecular formula:C8H7NO
Molecular Weight:133.15

24964-64-5 Synthesis

24964-64-5
331 suppliers
$9.00/1g

874-97-5
131 suppliers
$18.30/250mg

Yield: 99%

Reaction Conditions:

with [Ir(2,2':6',2'’-terpyridine)(1,10-phenanthroline)Cl](PF₆)₂;sodium formate in ethanol;water at 100; for 0.333333 h;Microwave irradiation;chemoselective reaction;

Steps:

A typical procedure for TH reaction:
General procedure: An aldehyde (1 mmol),sodium formate (4.5 eq), and catalyst (0.2 mol%) were taken in70% ethanol in water (4 mL) in a microwave vial and vortexed togenerate a homogenous solution. The mixture was heated in MWat 100 °C using 150W of irradiation. Reaction progress was monitored by TLC. If complete conversion took place, the reaction colorturns to emerald green (color disappears after sometime) from paleyellow, and byproduct Na2CO3 precipitates. The Na2CO3 solid wasremoved by decanting the supernatant. The solid was washed withethyl acetate (20 mL). The combined decanted solution waswashed with water (5.0 mL), followed by brine solution (5.0 mL),dried over Na2SO4, filtered, and evaporated to dryness to affordthe desired alcohol as a pale-yellow liquid or off-white solid.

References:

Pandrala, Mallesh;Resendez, Angel;Malhotra, Sanjay V. [Journal of Catalysis,2019,vol. 378,p. 283 - 288]