3-CHLOROPROPYL ISOTHIOCYANATE synthesis
- Product Name:3-CHLOROPROPYL ISOTHIOCYANATE
- CAS Number:2799-72-6
- Molecular formula:C4H6ClNS
- Molecular Weight:135.62
333-20-0
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109-70-6
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2799-72-6
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Yield:-
Reaction Conditions:
in tetrahydrofuran at 70; for 3 h;
Steps:
6.2 Step 2: The specific synthesis method for the synthesis of 3-chloroisothiocyanopropane from 1-bromo-3-chloropropane and thiocyanate is:
The thiocyanate was dissolved in 1.2 times its own molar amount of tetrahydrofuran, and heated slowly to 70 ° C at a temperature increase rate of less than 20 ° C / min. The molar ratio of 1-bromo-3-chloropropane to potassium thiocyanate was 1-bromo-3-chloropropane was slowly added dropwise to the potassium thiocyanate solution at 1:1, and the dropwise addition was completed after 1 h. After the completion of the dropwise addition, the original temperature was maintained for 2 h to complete the reaction;1-Bromo-3-chloropropane is reacted with potassium thiocyanate to form 3-chloroisothiocyanopropane and potassium bromide; after the reaction is completed, the reaction solution is cooled, filtered, and distilled under normal pressure or reduced pressure to collect the fraction. The 3-chloroisothiocyanopropane component is ready for use.
References:
CN110143901,2019,A Location in patent:Paragraph 0074; 0078; 0079
540-72-7
460 suppliers
$13.50/100G
109-70-6
496 suppliers
$10.00/5g
2799-72-6
31 suppliers
$15.00/500mg
463-71-8
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$32.00/10g
14753-26-5
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2799-72-6
31 suppliers
$15.00/500mg
463-71-8
152 suppliers
$32.00/10g
6276-54-6
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2799-72-6
31 suppliers
$15.00/500mg