ChemicalBook CAS DataBase List 3-Chloro-6-trifluoromethyl-pyridazine

3-Chloro-6-trifluoromethyl-pyridazine synthesis

5synthesis methods

Product Name:3-Chloro-6-trifluoromethyl-pyridazine
CAS Number:258506-68-2
Molecular formula:C5H2ClF3N2
Molecular Weight:182.53

174607-36-4 Synthesis

174607-36-4
88 suppliers
$35.00/100mg

258506-68-2
190 suppliers
$22.00/250mg

Yield:258506-68-2 92%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide for 2 h;Heating / reflux;

Steps:

Reference Example 313

Reference Example 313 A mixture of6- (trifluoromethyl)-3-pyridazinone (1.41 g), thionyl chloride (1.5 ml) and N, N-dimethylformamide (0.3 ml) was refluxed for 2 hours. Excess thionyl chloride was evaporated under reduced pressure and aqueous sodium hydrogen carbonate was added. The mixture was extracted with diethyl ether. The diethyl ether layer was washed with saturated brine, dried(MgS04) and concentrated. The residue was subjected to silica gel column chromatography, and 3-chloro-6- (trifluoromethyl) pyridazine (1.45 g, yield92%) was obtained as white crystals from a fraction eluted with ethyl acetate- hexane (1: 3, volume ratio). melting point:51-52 C.lH-NMR (CDC13) 6 : 7.75(1H, dd, J=8.7, 0.6 Hz), 7.82(1H, d, J=9.0Hz).

References:

WO2003/99793,2003,A1 Location in patent:Page 272

1514-87-0 Synthesis