3-chloro-6-Methoxy-[1,5]-naphthyridin-4-ol synthesis
- Product Name:3-chloro-6-Methoxy-[1,5]-naphthyridin-4-ol
- CAS Number:724787-12-6
- Molecular formula:C9H7ClN2O2
- Molecular Weight:210.62
23443-25-6
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Yield:724787-12-6 80%
Reaction Conditions:
with N-chloro-succinimide in acetic acid at 35; for 24 h;
Steps:
1.a
A solution of 6-(methyloxy)-l,5-naphthyridin-4-ol (6-methoxy-lH- [l,5]naphthyridin-4-one, for a synthesis see WO2002096907 Example 1) (50 g; 0.2841 mol) in glacial acetic acid (750 niL) was treated with N-chlorosuccinimide (42.5 g; 0.3185 mol) and the mixture was heated under argon at 350C for 24 hours. It was cooled and the precipitated solid filtered off and washed with a little cold acetic acid, then ether and finally hexane. It was dried at 5O0C overnight in vacuo to give an off-white solid 48g (80%). LC/MS (+ve ion electrospray): m/z 209/211 (M+η)+
References:
WO2008/6648,2008,A1 Location in patent:Page/Page column 23
6628-77-9
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![5 - [[(6 - Methoxypyridin - 3 - yl)aMino]Methylidene] - 2,2 - diMethyl - 1,3 - dioxane - 4,6 - dione](/CAS/20180713/GIF/25063-69-8.gif)
25063-69-8
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724787-12-6
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