3-CHLORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE synthesis
- Product Name:3-CHLORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE
- CAS Number:477535-43-6
- Molecular formula:C8H4ClF3O
- Molecular Weight:208.57
886496-87-3
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Yield: 62%
Reaction Conditions:
with manganese(IV) oxide in toluene at 50; for 14 h;
Steps:
95.5
(Step 5)A solution of the compound (1.00 g) obtained in step 4 and MnO2 (2.06 g) in toluene (30 mL) was stirred at 50° C. for 12 hr. MnO2 (2.06 g) was further added, and the mixture was stirred at 50° C. for 2 hr. Insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent; 5% ethyl acetate/hexane) to give 3-chloro-5-(trifluoromethyl)benzaldehyde (0.609 g, 62%) as a pale-yellow oil.1H-NMR (300 MHz, CDCl3):δ 7.86 (1H, s), 8.02 (1H, s), 8.04 (1H, s), 10.00 (1H, s)
References:
Shirai, Junya;Morimoto, Shinji;Sugiyama, Hideyuki;Sakauchi, Nobuki;Yoshikawa, Takeshi US2008/275085, 2008, A1 Location in patent:Page/Page column 45-46
328-80-3
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22227-63-0
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22235-25-2
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