3-CHLORO-4-FLUORO-DL-PHENYLGLYCINE synthesis
- Product Name:3-CHLORO-4-FLUORO-DL-PHENYLGLYCINE
- CAS Number:261762-99-6
- Molecular formula:C8H7ClFNO2
- Molecular Weight:203.6
261762-99-6
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Yield:-
Reaction Conditions:
in acetonitrile at 20; for 0.5 h;
Steps:
6A.A
308 309Part A:To a solution of compound 308 (0.15 mmol) in acetonitrile (2 mL) and methanol (2 mL) was added (trimethylsilyl)diazomethane (2M, 0.11 mL, 0.22 mmol). The reaction mixture was stirred at room temperature for 30 minutes. LC-MS analysis of the reaction indicated that the reaction was complete. The volatiles were removed in vacuo to afford compound 309 as a white solid. HPLC-MS tR = 0.82 min (UV254 nm); mass calculated for formula C9H9CIFNO2 217.0, observed LCMS m/z 218.1 (M+H).
References:
WO2008/82490,2008,A2 Location in patent:Page/Page column 155