ChemicalBook CAS DataBase List 3-(BROMOMETHYL)-1,2-BENZISOXAZOLE

3-(BROMOMETHYL)-1,2-BENZISOXAZOLE synthesis

8synthesis methods

Product Name:3-(BROMOMETHYL)-1,2-BENZISOXAZOLE
CAS Number:37924-85-9
Molecular formula:C8H6BrNO
Molecular Weight:212.04

37924-67-7
49 suppliers
$97.90/25MG

37924-85-9
108 suppliers
$80.00/2mg

Yield:37924-85-9 76%

Reaction Conditions:

with sulfuric acid for 4 h;Reflux;

Steps:

6.1; 7.1; 8.1 (1) Preparation method of compound (Z-5) of formula (V) as starting material:

Compound Z-1 (1.42.0 g, 8.0 mmol) synthesized above was dissolved in 5 mL of glacial acetic acid, and bromine (0.45 mL, 8.8 mmol) was slowly added dropwise with stirring (dropwise time 30 min), and the reaction was carried out at room temperature for 6 h, the reaction solution was then poured into ice water (20 ml), stirred, the solid was precipitated, filtered, and the filter cake was dried to obtain light yellow solid Z-4 (1.74 g, yield 85%). Compound Z-4 (1.74 g, 6.8 mmol) was dissolved in 20% sulfuric acid (6 mL), refluxed under stirring for 4 h, then cooled to room temperature, filtered and steam distilled to obtain 1.28 g of white crystal Z-5, namely It is the compound of formula (V), the yield is 76%

References:

CN113651767,2021,A Location in patent:Paragraph 0038; 0041; 0044

4825-75-6 Synthesis