3-Bromo-N-cyclohexylbenzamide synthesis
- Product Name:3-Bromo-N-cyclohexylbenzamide
- CAS Number:59507-55-0
- Molecular formula:C13H16BrNO
- Molecular Weight:282.18
1711-09-7
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108-91-8
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59507-55-0
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Yield:59507-55-0 95%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 2 h;
Steps:
163.1 Example 163 Preparation of 3-(3-aminopropyl)-o-cyclohexylbenzamide
Step 1:
A solution of 3-bromobenzoyl chloride (2.0 g, 9.1 mmol) in CH2Cl2 was added to a solution triethylamine (1.9 ml, 13.7 mmol) and cyclohexylamine (1.15 ml, 10.0 mmol) in CH2Cl2 at room temperature with stirring.
After 2 h, the mixture was washed with HCl (4N), brine, dried over Na2SO4 and concentrated under reduced pressure to give 3-bromo-N-cyclohexylbenzamide as a white solid.
Yield (2.43 g, 95%): 1H NMR (400 MHz, CD3OD) δ 8.29 (br s, 1H), 7.95 (t, J=2.0 Hz, 1H), 7.42-7.77 (m, 1H), 7.64-7.67 (m, 1H), 7.36 (t, J=8.0 Hz, 1H), 3.78-3.84 (m, 1H), 1.92-1.94 (m, 2H), 1.78-1.81 (m, 2H), 1.65-1.69 (m, 1H), 1.16-1.46 (m, 5H).
References:
US2016/193181,2016,A1 Location in patent:Paragraph 2079
3132-99-8
495 suppliers
$5.00/10g
108-91-8
612 suppliers
$10.00/5mL
59507-55-0
23 suppliers
$131.00/1g