3-BIPHENYL-4-YL-3-OXO-PROPIONIC ACID ETHYL ESTER synthesis
- Product Name:3-BIPHENYL-4-YL-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS Number:57477-98-2
- Molecular formula:C17H16O3
- Molecular Weight:268.31
61117-58-6
0 suppliers
inquiry
92-66-0
569 suppliers
$10.00/1g
6148-64-7
397 suppliers
$5.00/10g
57477-98-2
41 suppliers
$424.00/1g
Yield:57477-98-2 90%
Reaction Conditions:
with 1H-imidazole;palladium diacetate;triethylamine;4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;magnesium chloride in tetrahydrofuran at 90; for 0.5 h;Microwave irradiation;
Steps:
To a stirred mixture of aryl or heteroaryl halide(Br, I) (0.5 mmol), potassium mono ethyl malonate (0.75 mmol) in THF (10 mL) taken in a 30 mL microwave vial, was added Pd(OAc)2(5 mol%), Xantphos (5 mol %), MgCl2 (0.75), Et3N ( 0.75mmol), imidazole (1 mmol) followed by Co2(CO)8 (0.15mmol). The vial was sealed immediately and microwave irradiated at 90°C for 30min. The reaction mixture was concentrated and diluted with ethyl acetate and water. The ethyl acetate layer was separated, dried over sodium sulphate and concentrated. The crude product obtained was purified by column chromatography to get the pure compound.
References:
Baburajan, Poongavanam;Elango, Kuppanagounder P. [Tetrahedron Letters,2014,vol. 55,# 25,p. 3525 - 3528] Location in patent:supporting information
92-91-1
410 suppliers
$10.00/5g
105-58-8
460 suppliers
$15.00/25g
57477-98-2
41 suppliers
$424.00/1g
61117-58-6
0 suppliers
inquiry
1591-31-7
336 suppliers
$8.00/5g
6148-64-7
397 suppliers
$5.00/10g
57477-98-2
41 suppliers
$424.00/1g
1071-46-1
294 suppliers
$5.00/1g
14002-51-8
197 suppliers
$21.00/1g
57477-98-2
41 suppliers
$424.00/1g
17763-78-9
37 suppliers
$40.00/250mg
6148-64-7
397 suppliers
$5.00/10g
82102-37-2
14 suppliers
$45.00/50mg
57477-98-2
41 suppliers
$424.00/1g