ChemicalBook CAS DataBase List 3-AMINOHEPTANE

3-AMINOHEPTANE synthesis

6synthesis methods

Product Name:3-AMINOHEPTANE
CAS Number:28292-42-4
Molecular formula:C7H17N
Molecular Weight:115.22

4164-92-5
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28292-42-4
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Yield:28292-42-4 66%

Reaction Conditions:

with trichloroisocyanuric acid;sodium hydroxide in water;acetonitrile at 0; for 1.5 h;Reflux;Hofmann Rearrangement;Reagent/catalyst;

Steps:

General procedures for the Hofmann reaction mediated by trihaloisocyanuricacids.

General procedure: (a) Carboxamides: A solution of the carboxamide (20 mmol) and NaOH(4.4 g, 110 mmol) in H2O (15 mL) and MeCN (25 mL) was poured into a coldsuspension of the trihaloisocyanuric acid (6.7 mmol) in water (10 mL), stirredfor 1 h at 0 oC and then heated under reflux for 30 min. After cooling, the solid(cyanuric acid) was filtered off, and the filtrate was extracted withdichloromethane (3 x 20 mL). The combined layers were dried (Na2SO4)and the solvent evaporated to give the amine.

References:

Bastos, Gustavo A.;de Mattos, Marcio C.S. [Tetrahedron Letters,2021,vol. 83,art. no. 153422]

106-35-4 Synthesis