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ChemicalBook CAS DataBase List 3-Amino-5-chloropicoline
89639-36-1

3-Amino-5-chloropicoline synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 3.83 h / 20 °C / Inert atmosphere
1.2: 12.5 h / Reflux
1.3: pH 9
2.1: tin(II) chloride dihdyrate / ethyl acetate / 3 h / 85 °C / Inert atmosphere

References:

GLAXOSMITHKLINE LLC;BOBKO, Mark, A.;DARCY, Michael, G.;EVANS, Karen, A.;FAITG, Thomas, H.;KAURA, Arun, Chandar;PENG, Xin;SARPONG, Martha, A.;SEEFELD, Mark, A.;SU, Dai-shi WO2012/149102, 2012, A1

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