3-AMINO-3-(3,5-DIFLUORO-PHENYL)-PROPIONIC ACID synthesis
- Product Name:3-AMINO-3-(3,5-DIFLUORO-PHENYL)-PROPIONIC ACID
- CAS Number:682804-73-5
- Molecular formula:C9H9F2NO2
- Molecular Weight:201.17
141-82-2
760 suppliers
$5.00/25g
32085-88-4
264 suppliers
$19.00/25g
682804-73-5
25 suppliers
inquiry
Yield:682804-73-5 56%
Reaction Conditions:
with ammonium acetate in ethanol;Reflux;
Steps:
The mixture of 3, 5-difluorobenzylaldehyde (S1) (27.09 g, 0.19 mol, 1.0 equiv.), malonic acid (19.84 g, 0.19 mol, 1.0 equiv.), and ammonium acetate (29.39 g, 0.38 mol, 2.0 equiv.) in ethanol (300 mL) was stirred under reflux overnight. The white precipitate was filtered, rinsed with cold ethanol, dried under vacuum, and compound S2 was obtained (21.28 g, 0.11mol, 56% yield). 1H NMR (CD3OD): δ: 7.18-7.05 (m, 2 H); 7.00-6.95 (m, 1H), 4.53 (t, J = 7.0 Hz, 1H), 2.66 (d, J = 7.2 Hz, 2H). Electrospray MS: Obs. [M+H]: 202.1.
References:
WO2010/56722,2010,A1 Location in patent:Page/Page column 334