3-AMINO-1,1'-BIPHENYL-4-CARBOXYLICACID synthesis

11synthesis methods

Product Name:3-AMINO-1,1'-BIPHENYL-4-CARBOXYLICACID
CAS Number:4445-43-6
Molecular formula:C13H11NO2
Molecular Weight:213.23

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4445-43-6
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Yield:4445-43-6 95.9%

Reaction Conditions:

with water;sodium hydroxide in tetrahydrofuran at 25; for 12 h;Reagent/catalyst;Solvent;

Steps:

285; 308 Synthesis of compound 285.1.

Into a 100-mL round-bottom flask, was placed 249.1 (200 mg, 0.880 mmol, 1 equiv), H₂O (5 mL), THF (5 mL), and NaOH (351.9 mg, 8.800 mmol, 10 equiv). The resulting solution was stirred for 12 h at 25 ^oC. The reaction was then quenched by the addition of 20 mL of dilute hydrochloric acid. The resulting solution was extracted with 3 x 30 mL of ethyl acetate, and the combined organic layers were concentrated under vacuum. This resulted in 180 mg (95.9%) of 285.1 as a yellow solid.

References:

WO2020/97408,2020,A1 Location in patent:Paragraph 00842; 00897

20776-50-5 Synthesis