ChemicalBook CAS DataBase List 3-(9H-Carbazole-9-yl)-9H-carbazole

3-(9H-Carbazole-9-yl)-9H-carbazole synthesis

11synthesis methods

Product Name:3-(9H-Carbazole-9-yl)-9H-carbazole
CAS Number:18628-07-4
Molecular formula:C24H16N2
Molecular Weight:332.4

3,9'-Bi-9H-carbazole, 9-[(4-methylphenyl)sulfonyl]-

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Yield:18628-07-4 86%

Reaction Conditions:

with water;sodium hydroxide in tetrahydrofuran;methanol at 80; for 24 h;

Steps:

2 9H-3,9'-bicarbazole

To a solution of 9-tosyl-9H-3,9'- bicarbazole or IC-2 (8.6 g, 17.6 mmol) in THF (150 mL) and methanol (60 mL), was added sodium hydroxide aqueous solution (10 g in 60 mL water). The mixture was heated at 80 °C for 24 hours on a hot plate with a silicone oil bath. The resulting mixture was mixed with ethyl acetate and rinsed with brine, then loaded on silica gel (Grade 135) and purified by flash chromatography using eluents of ethyl acetate/hexanes (0% to 10%). After removal of solvents, the product was then collected to yield a white solid (Compound OSC-6) (5.0 g, in 86% yield). Confirmed by ¹ HNMR.

References:

WO2015/195837,2015,A1 Location in patent:Paragraph 0061; 0064

1592-95-6 Synthesis