3,5-dichloropyridazin-4-amine synthesis
- Product Name:3,5-dichloropyridazin-4-amine
- CAS Number:53180-76-0
- Molecular formula:C4H3Cl2N3
- Molecular Weight:163.99
14161-11-6
151 suppliers
$9.00/1g
53180-76-0
82 suppliers
$61.00/100mg
Yield:53180-76-0 36%
Reaction Conditions:
with ammonium hydroxide in ethanol at 120; for 0.416667 h;Microwave irradiation;
Steps:
4 3,5-Dichloropyridazin-4-amine
A mixture of 3,4,5-trichloropyridazine (Preparation 3, 500 mg, 2.73 mmole) in EtOH (5.5 mL) and NH4OH (5.5 mL) was heated under microwave irradiation 120° C. for 25 minutes. Concentration under reduced pressure and purification via silica gel column chromatography eluting with acetone:dichloromethane (0-15% acetone), provided the title product in 36% yield, 163 mg. 1H NMR (400 MHz, CDCl3): δ ppm 5.11 (br s, 2H), 8.74 (s, 1H). LCMS Rt=0.27 minutes MS m/z 164 [M+H]+
References:
US2014/171435,2014,A1 Location in patent:Paragraph 0454; 0455; 0456
14161-11-6
151 suppliers
$9.00/1g
89180-50-7
60 suppliers
$39.00/100mg
53180-76-0
82 suppliers
$61.00/100mg
14161-11-6
151 suppliers
$9.00/1g
7664-41-7
510 suppliers
$15.00/100ml
89180-50-7
60 suppliers
$39.00/100mg
53180-76-0
82 suppliers
$61.00/100mg